NIOSH Publication No. 2005-151:

NIOSH Pocket Guide to Chemical Hazards

September 2005

Acetone cyanohydrin

CAS
75-86-5

CH3C(OH)CNCH3

RTECS
OD9275000
Synonyms & Trade Names

Cyanohydrin-2-propanone, 2-Cyano-2-propanol, alpha-Hydroxyisobutyronitrile, 2-Hydroxy-2-methyl-propionitrile, 2-Methyllactonitrile
DOT ID & Guide
1541 / 155 (stabilized)

Exposure
Limits

NIOSH REL: C 1 ppm (4 mg/m3) [15-minute]
OSHA PEL: none
IDLH
N.D. See: IDLH INDEX
Conversion
1 ppm = 3.48 mg/m3
Physical Description
Colorless liquid with a faint odor of bitter almond. [Note: Forms cyanide in the body.]
MW: 85.1
BP: 203°F
FRZ: -4°F
Sol: Miscible
VP: 0.8 mmHg
IP: ?

Sp.Gr(77°F): 0.93
Fl.P: 165°F
UEL: 12.0%
LEL: 2.2%

Class IIIA Combustible Liquid: Fl.P. at or above 140F and below 200F.
Incompatibilities & Reactivities

Sulfuric acid, caustics [Note: Slowly decomposes to acetone & HCN at room temperatures; rate is accelerated by an increase in pH, water content, or temperature.]
Measurement Methods
NIOSH 2506
See: NMAM or OSHA Methods
Personal Protection & Sanitation
(See protection)
Skin: Prevent skin contact
Eyes: Prevent eye contact
Wash skin: When contaminated
Remove: When wet or contaminated
Change: No recommendation
Provide: Eyewash, Quick drench
First Aid
(See procedures)
Eye: Irrigate immediately
Skin: Water flush immediately
Breathing: Respiratory support
Swallow: Medical attention immediately
Respirator Recommendations
NIOSH
Up to 10 ppm:
(APF = 10) Any supplied-air respirator
Up to 25 ppm:
(APF = 25) Any supplied-air respirator operated in a continuous-flow mode
Up to 50 ppm:
(APF = 50) Any self-contained breathing apparatus with a full facepiece
(APF = 50) Any supplied-air respirator with a full facepiece
Up to 250 ppm:
(APF = 2000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
Emergency or planned entry into unknown concentrations or IDLH conditions:
(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
Escape:
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus
Important additional information about respirator selection
Exposure Routes
inhalation, skin absorption, ingestion, skin and/or eye contact
Symptoms
Irritation eyes, skin, respiratory system; dizziness, lassitude (weakness, exhaustion), headache, confusion, convulsions; liver, kidney injury; pulmonary edema, asphyxia
Target Organs
Eyes, skin, respiratory system, central nervous system, cardiovascular system, liver, kidneys, gastrointestinal tract
See also: INTRODUCTION   See ICSC CARD: 0611