NIOSH Publication No. 2005-151:

NIOSH Pocket Guide to Chemical Hazards

September 2005




Synonyms & Trade Names

Benzidine-based dyes; 4,4'-Bianiline; 4,4'-Biphenyldiamine; 1,1'-Biphenyl-4,4'-diamine; 4,4'-Diaminobiphenyl; p-Diaminodiphenyl [Note: Benzidine has been used as a basis for many dyes.]
DOT ID & Guide
1885 / 153


NIOSH REL: Ca See Appendix A See Appendix C
OSHA PEL: [1910.1010] See Appendix B See Appendix C
Physical Description
Grayish-yellow, reddish-gray, or white crystalline powder. [Note: Darkens on exposure to air and light.]
MW: 184.3
BP: 752°F
MLT: 239°F
Sol(54°F): 0.04%
VP: Low
IP: ?

Sp.Gr: 1.25
Fl.P: ?
UEL: ?
LEL: ?

Combustible Solid, but difficult to burn.
Incompatibilities & Reactivities

Red fuming nitric acid
Measurement Methods
NIOSH 5509; OSHA 65
See: NMAM or OSHA Methods
Personal Protection & Sanitation
(See protection)
Skin: Prevent skin contact
Eyes: Prevent eye contact
Wash skin: When contaminated/Daily
Remove: When wet or contaminated
Change: Daily
Provide: Eyewash, Quick drench
First Aid
(See procedures)
Eye: Irrigate immediately
Skin: Soap wash immediately
Breathing: Respiratory support
Swallow: Medical attention immediately
Respirator Recommendations
(See Appendix E) NIOSH
At concentrations above the NIOSH REL, or where there is no REL, at any detectable concentration:
(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
(APF = 50) Any air-purifying, full-facepiece respirator with an N100, R100, or P100 filter. Click here for information on selection of N, R, or P filters./Any appropriate escape-type, self-contained breathing apparatus
Important additional information about respirator selection
Exposure Routes
inhalation, skin absorption, ingestion, skin and/or eye contact
Hematuria (blood in the urine); secondary anemia from hemolysis; acute cystitis; acute liver disorders; dermatitis; painful, irregular urination; [potential occupational carcinogen]
Target Organs
Bladder, skin, kidneys, liver, blood

Cancer Site
[liver, kidney & bladder cancer]
See also: INTRODUCTION   See ICSC CARD: 0224   See MEDICAL TESTS: 0023