NIOSH Publication No. 2005-151:

NIOSH Pocket Guide to Chemical Hazards

September 2005

Dimethylformamide

CAS
68-12-2

HCON(CH3)2

RTECS
LQ2100000
Synonyms & Trade Names

Dimethyl formamide; N,N-Dimethylformamide; DMF
DOT ID & Guide
2265 / 129

Exposure
Limits

NIOSH REL: TWA 10 ppm (30 mg/m3) [skin]
OSHA PEL: TWA 10 ppm (30 mg/m3) [skin]
IDLH
500 ppm See: 68122
Conversion
1 ppm = 2.99 mg/m3
Physical Description
Colorless to pale-yellow liquid with a faint, amine-like odor.
MW: 73.1
BP: 307°F
FRZ: -78°F
Sol: Miscible
VP: 3 mmHg
IP: 9.12 eV

Sp.Gr: 0.95
Fl.P: 136°F
UEL: 15.2%
LEL(212°F): 2.2%

Class II Combustible Liquid: Fl.P. at or above 100F and below 140F.
Incompatibilities & Reactivities

Carbon tetrachloride; other halogenated compounds when in contact with iron; strong oxidizers; alkyl aluminums; inorganic nitrates
Measurement Methods
NIOSH 2004; OSHA 66
See: NMAM or OSHA Methods
Personal Protection & Sanitation
(See protection)
Skin: Prevent skin contact
Eyes: Prevent eye contact
Wash skin: When contaminated
Remove: When wet or contaminated
Change: No recommendation

First Aid
(See procedures)
Eye: Irrigate immediately
Skin: Water flush promptly
Breathing: Respiratory support
Swallow: Medical attention immediately
Respirator Recommendations
NIOSH
Up to 100 ppm:
(APF = 10) Any supplied-air respirator*
Up to 250 ppm:
(APF = 25) Any supplied-air respirator operated in a continuous-flow mode*
Up to 500 ppm:
(APF = 50) Any supplied-air respirator that has a tight-fitting facepiece and is operated in a continuous-flow mode*
(APF = 50) Any self-contained breathing apparatus with a full facepiece
(APF = 50) Any supplied-air respirator with a full facepiece
Emergency or planned entry into unknown concentrations or IDLH conditions:
(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
Escape:
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus
Important additional information about respirator selection
Exposure Routes
inhalation, skin absorption, ingestion, skin and/or eye contact
Symptoms
Irritation eyes, skin, respiratory system; nausea, vomiting, colic; liver damage, enlarged liver; high blood pressure; face flush; dermatitis; in animals: kidney, heart damage
Target Organs
Eyes, skin, respiratory system, liver, kidneys, cardiovascular system
See also: INTRODUCTION   See ICSC CARD: 0457   See MEDICAL TESTS: 0091