NIOSH Publication No. 2005-151:

NIOSH Pocket Guide to Chemical Hazards

September 2005

Hexamethylene diisocyanate

CAS
822-06-0

OCN[CH2]6NCO

RTECS
MO1740000
Synonyms & Trade Names

1,6-Diisocyanatohexane; HDI; Hexamethylene-1,6-diisocyanate; 1,6-Hexamethylene diisocyanate; HMDI
DOT ID & Guide
2281 / 156

Exposure
Limits

NIOSH REL: TWA 0.005 ppm (0.035 mg/m3) C 0.020 ppm (0.140 mg/m3) [10-minute]
OSHA PEL: none
IDLH
N.D. See: IDLH INDEX
Conversion
1 ppm = 6.88 mg/m3
Physical Description
Clear, colorless to slightly yellow liquid with a sharp, pungent odor.
MW: 168.2
BP: 415°F
FRZ: -89°F
Sol: Low (Reacts)
VP(77°F): 0.5 mmHg
IP:?

Sp.Gr(77°F): 1.04
Fl.P: 284°F
UEL: ?
LEL: ?

Class IIIB Combustible Liquid: Fl.P. at or above 200F.
Incompatibilities & Reactivities

Water, alcohols, strong bases, amines, carboxylic acids, organotin catalysts [Note: Reacts slowly with water to form carbon dioxide. Avoid heating above 392°F (polymerizes).]
Measurement Methods
NIOSH 5521, 5522, 5525; OSHA 42
See: NMAM or OSHA Methods
Personal Protection & Sanitation
(See protection)
Skin: Prevent skin contact
Eyes: Prevent eye contact
Wash skin: When contaminated
Remove: When wet or contaminated
Change: No recommendation
Provide: Eyewash, Quick drench
First Aid
(See procedures)
Eye: Irrigate immediately
Skin: Soap flush immediately
Breathing: Respiratory support
Swallow: Medical attention immediately
Respirator Recommendations
NIOSH
Up to 0.05 ppm:
(APF = 10) Any supplied-air respirator*
Up to 0.125 ppm:
(APF = 25) Any supplied-air respirator operated in a continuous-flow mode*
Up to 0.25 ppm:
(APF = 50) Any self-contained breathing apparatus with a full facepiece
(APF = 50) Any supplied-air respirator with a full facepiece
Up to 1 ppm:
(APF = 2000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
Emergency or planned entry into unknown concentrations or IDLH conditions:
(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
Escape:
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus
Important additional information about respirator selection
Exposure Routes
inhalation, ingestion, skin and/or eye contact
Symptoms
Irritation eyes, skin, respiratory system; cough, dyspnea (breathing difficulty), bronchitis, wheezing, pulmonary edema, asthma; corneal damage, skin blisters
Target Organs
Eyes, skin, respiratory system
See also: INTRODUCTION   See ICSC CARD: 0278