NIOSH Publication No. 2005-151:

NIOSH Pocket Guide to Chemical Hazards

September 2005

Hexone

CAS
108-10-1

CH3COCH2CH(CH3)2

RTECS
SA9275000
Synonyms & Trade Names

Isobutyl methyl ketone, Methyl isobutyl ketone, 4-Methyl 2-pentanone, MIBK
DOT ID & Guide
1245 / 127

Exposure
Limits

NIOSH REL: TWA 50 ppm (205 mg/m3) ST 75 ppm (300 mg/m3)
OSHA PEL: TWA 100 ppm (410 mg/m3)
IDLH
500 ppm See: 108101
Conversion
1 ppm = 4.10 mg/m3
Physical Description
Colorless liquid with a pleasant odor.
MW: 100.2
BP: 242°F
FRZ: -120°F
Sol: 2%
VP: 16 mmHg
IP: 9.30 eV

Sp.Gr: 0.80
Fl.P: 64°F
UEL(200°F): 8.0%
LEL(200°F): 1.2%

Class IB Flammable Liquid: Fl.P. below 73F and BP at or above 100F.
Incompatibilities & Reactivities

Strong oxidizers, potassium tert-butoxide
Measurement Methods
NIOSH 1300, 2555; OSHA 1004
See: NMAM or OSHA Methods
Personal Protection & Sanitation
(See protection)
Skin: Prevent skin contact
Eyes: Prevent eye contact
Wash skin: When contaminated
Remove: When wet (flammable)
Change: No recommendation

First Aid
(See procedures)
Eye: Irrigate immediately
Skin: Water flush promptly
Breathing: Respiratory support
Swallow: Medical attention immediately
Respirator Recommendations
NIOSH
Up to 500 ppm:
(APF = 10) Any chemical cartridge respirator with organic vapor cartridge(s)*
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister
(APF = 50) Any powered, air-purifying respirator with a tight-fitting facepiece and organic vapor cartridge(s)*
(APF = 10) Any supplied-air respirator*
(APF = 50) Any self-contained breathing apparatus with a full facepiece
Emergency or planned entry into unknown concentrations or IDLH conditions:
(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
Escape:
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus
Important additional information about respirator selection
Exposure Routes
inhalation, ingestion, skin and/or eye contact
Symptoms
Irritation eyes, skin, mucous membrane; headache, narcosis, coma; dermatitis; in animals: liver, kidney damage
Target Organs
Eyes, skin, respiratory system, central nervous system, liver, kidneys
See also: INTRODUCTION   See ICSC CARD: 0511   See MEDICAL TESTS: 0134