NIOSH Publication No. 2005-151:

NIOSH Pocket Guide to Chemical Hazards

September 2005

Isophorone

CAS
78-59-1

C9H14O

RTECS
GW7700000
Synonyms & Trade Names

Isoacetophorone; 3,5,5-Trimethyl-2-cyclohexenone; 3,5,5-Trimethyl-2-cyclo-hexen-1-one
DOT ID & Guide
1993 / 128 (combustible liquid, n.o.s.)

Exposure
Limits

NIOSH REL: TWA 4 ppm (23 mg/m3)
OSHA PEL: TWA 25 ppm (140 mg/m3)
IDLH
200 ppm See: 78591
Conversion
1 ppm = 5.65 mg/m3
Physical Description
Colorless to white liquid with a peppermint-like odor.
MW: 138.2
BP: 419°F
FRZ: 17°F
Sol: 1%
VP: 0.3 mmHg
IP: 9.07 eV

Sp.Gr: 0.92
Fl.P: 184°F
UEL: 3.8%
LEL: 0.8%

Class IIIA Combustible Liquid: Fl.P. at or above 140F and below 200F.
Incompatibilities & Reactivities

Oxidizers, strong alkalis, amines
Measurement Methods
NIOSH 2508, 2556; OSHA 7
See: NMAM or OSHA Methods
Personal Protection & Sanitation
(See protection)
Skin: Prevent skin contact
Eyes: Prevent eye contact
Wash skin: When contaminated
Remove: When wet or contaminated
Change: No recommendation
Provide: Eyewash
First Aid
(See procedures)
Eye: Irrigate immediately
Skin: Soap wash promptly
Breathing: Respiratory support
Swallow: Medical attention immediately
Respirator Recommendations
NIOSH
Up to 40 ppm:
(APF = 10) Any chemical cartridge respirator with organic vapor cartridge(s)*
(APF = 10) Any supplied-air respirator*
Up to 100 ppm:
(APF = 25) Any supplied-air respirator operated in a continuous-flow mode*
(APF = 25) Any powered, air-purifying respirator with organic vapor cartridge(s)*
Up to 200 ppm:
(APF = 50) Any chemical cartridge respirator with a full facepiece and organic vapor cartridge(s)
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister
(APF = 50) Any powered, air-purifying respirator with a tight-fitting facepiece and organic vapor cartridge(s)*
(APF = 50) Any supplied-air respirator that has a tight-fitting facepiece and is operated in a continuous-flow mode*
(APF = 50) Any self-contained breathing apparatus with a full facepiece
(APF = 50) Any supplied-air respirator with a full facepiece
Emergency or planned entry into unknown concentrations or IDLH conditions:
(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
Escape:
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus
Important additional information about respirator selection
Exposure Routes
inhalation, ingestion, skin and/or eye contact
Symptoms
Irritation eyes, nose, throat; headache, nausea, dizziness, lassitude (weakness, exhaustion), malaise (vague feeling of discomfort), narcosis; dermatitis; in animals: kidney, liver damage
Target Organs
Eyes, skin, respiratory system, central nervous system, liver, kidneys
See also: INTRODUCTION   See ICSC CARD: 0169   See MEDICAL TESTS: 0123