NIOSH Publication No. 2005-151:

NIOSH Pocket Guide to Chemical Hazards

September 2005

Isophorone diisocyanate

CAS
4098-71-9

C12H18N2O2

RTECS
NQ9370000
Synonyms & Trade Names

IPDI; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl-isocyanate; Isophorone diamine diisocyanate
DOT ID & Guide
2290 / 156

Exposure
Limits

NIOSH REL: TWA 0.005 ppm (0.045 mg/m3) ST 0.02 ppm (0.180 mg/m3) [skin]
OSHA PEL: none
IDLH
N.D. See: IDLH INDEX
Conversion
1 ppm = 9.09 mg/m3
Physical Description
Colorless to slightly yellow liquid with a pungent odor.
MW: 222.3
BP: ?
FRZ: -76°F
Sol: Decomposes
VP: 0.0003 mmHg
IP: ?

Sp.Gr: 1.06
Fl.P: 311°F
UEL: ?
LEL: ?

Class IIIB Combustible Liquid: Fl.P. at or above 200F.
Incompatibilities & Reactivities

Water, alcohols, phenols, amines, mercaptans, amides, urethanes, ureas [Note: Reacts with water to form carbon dioxide.]
Measurement Methods
NIOSH 5525; OSHA PV2034
See: NMAM or OSHA Methods
Personal Protection & Sanitation
(See protection)
Skin: Prevent skin contact
Eyes: Prevent eye contact
Wash skin: When contaminated
Remove: When wet or contaminated
Change: Daily
Provide: Quick drench
First Aid
(See procedures)
Eye: Irrigate immediately
Skin: Water flush immediately
Breathing: Respiratory support
Swallow: Medical attention immediately
Respirator Recommendations
NIOSH
Up to 0.05 ppm:
(APF = 10) Any supplied-air respirator*
Up to 0.125 ppm:
(APF = 25) Any supplied-air respirator operated in a continuous-flow mode*
Up to 0.25 ppm:
(APF = 50) Any self-contained breathing apparatus with a full facepiece
(APF = 50) Any supplied-air respirator with a full facepiece
Up to 1 ppm:
(APF = 2000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
Emergency or planned entry into unknown concentrations or IDLH conditions:
(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
Escape:
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus
Important additional information about respirator selection
Exposure Routes
inhalation, skin absorption, ingestion, skin and/or eye contact
Symptoms
Irritation eyes, skin, respiratory system; chest tightness, dyspnea (breathing difficulty), cough, sore throat; bronchitis, wheezing, pulmonary edema; possible respiratory sensitization, asthma
Target Organs
Eyes, skin, respiratory system
See also: INTRODUCTION   See ICSC CARD: 0499