NIOSH Publication No. 2005-151:

NIOSH Pocket Guide to Chemical Hazards

September 2005

Methyl isoamyl ketone

CAS
110-12-3

CH3COCH2CH2CH(CH3)2

RTECS
MP3850000
Synonyms & Trade Names

Isoamyl methyl ketone, Isopentyl methyl ketone, 2-Methyl-5-hexanone, 5-Methyl-2-hexanone, MIAK
DOT ID & Guide
2302 / 127

Exposure
Limits

NIOSH REL: TWA 50 ppm (240 mg/m3)
OSHA PEL: TWA 100 ppm (475 mg/m3)
IDLH
N.D. See: IDLH INDEX
Conversion
1 ppm = 4.67 mg/m3
Physical Description
Colorless, clear liquid with a pleasant, fruity odor.
MW: 114.2
BP: 291°F
FRZ: -101°F
Sol: 0.5%
VP: 5 mmHg
IP: 9.284 eV

Sp.Gr: 0.81
Fl.P: 97°F
UEL(200°F): 8.2%
LEL(200°F): 1.0%

Class IC Flammable Liquid: Fl.P. at or above 73F and below 100F.
Incompatibilities & Reactivities

Oxidizers
Measurement Methods
OSHA PV2042
See: NMAM or OSHA Methods
Personal Protection & Sanitation
(See protection)
Skin: Prevent skin contact
Eyes: Prevent eye contact
Wash skin: When contaminated
Remove: When wet (flammable)
Change: No recommendation

First Aid
(See procedures)
Eye: Irrigate immediately
Skin: Soap flush promptly
Breathing: Respiratory support
Swallow: Medical attention immediately
Respirator Recommendations
NIOSH
Up to 500 ppm:
(APF = 10) Any chemical cartridge respirator with organic vapor cartridge(s)*
(APF = 10) Any supplied-air respirator*
Up to 1250 ppm:
(APF = 25) Any supplied-air respirator operated in a continuous-flow mode*
(APF = 25) Any powered, air-purifying respirator with organic vapor cartridge(s)*
Up to 2500 ppm:
(APF = 50) Any chemical cartridge respirator with a full facepiece and organic vapor cartridge(s)
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister
(APF = 50) Any powered, air-purifying respirator with a tight-fitting facepiece and organic vapor cartridge(s)*
(APF = 50) Any supplied-air respirator that has a tight-fitting facepiece and is operated in a continuous-flow mode*
(APF = 50) Any self-contained breathing apparatus with a full facepiece
(APF = 50) Any supplied-air respirator with a full facepiece
Up to 5000 ppm:
(APF = 2000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
Emergency or planned entry into unknown concentrations or IDLH conditions:
(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
Escape:
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus
Important additional information about respirator selection
Exposure Routes
inhalation, ingestion, skin and/or eye contact
Symptoms
Irritation eyes, skin, mucous membrane; headache, narcosis, coma; dermatitis; in animals: liver, kidney damage
Target Organs
Eyes, skin, respiratory system, central nervous system, liver, kidneys
See also: INTRODUCTION   See ICSC CARD: 0815