NIOSH Publication No. 2005-151:

NIOSH Pocket Guide to Chemical Hazards

September 2005

Propionitrile

CAS
107-12-0

CH3CH2CN

RTECS
UF9625000
Synonyms & Trade Names

Cyanoethane, Ethyl cyanide, Propanenitrile, Propionic nitrile, Propiononitrile
DOT ID & Guide
2404 / 131

Exposure
Limits

NIOSH REL: TWA 6 ppm (14 mg/m3)
OSHA PEL: none
IDLH
N.D. See: IDLH INDEX
Conversion
1 ppm = 2.25 mg/m3
Physical Description
Colorless liquid with a pleasant, sweetish, ethereal odor. [Note: Forms cyanide in the body.]
MW: 55.1
BP: 207°F
FRZ: -133°F
Sol: 11.9%
VP: 35 mmHg
IP: 11.84 eV

Sp.Gr: 0.78
Fl.P: 36°F
UEL: ?
LEL: 3.1%

Class IB Flammable Liquid: Fl.P. below 73F and BP at or above 100F.
Incompatibilities & Reactivities

Strong oxidizers & reducing agents, strong acids & bases [Note: Hydrogen cyanide is produced when propionitrile is heated to decomposition.]
Measurement Methods
NIOSH 1606 (adapt)
See: NMAM or OSHA Methods
Personal Protection & Sanitation
(See protection)
Skin: Prevent skin contact
Eyes: Prevent eye contact
Wash skin: When contaminated
Remove: When wet or contaminated
Change: No recommendation
Provide: Quick drench
First Aid
(See procedures)
Eye: Irrigate immediately
Skin: Water flush immediately
Breathing: Respiratory support
Swallow: Medical attention immediately
Respirator Recommendations
NIOSH
Up to 60 ppm:
(APF = 10) Any chemical cartridge respirator with organic vapor cartridge(s)
(APF = 10) Any supplied-air respirator
Up to 150 ppm:
(APF = 25) Any supplied-air respirator operated in a continuous-flow mode
(APF = 25) Any powered, air-purifying respirator with organic vapor cartridge(s)
Up to 300 ppm:
(APF = 50) Any chemical cartridge respirator with a full facepiece and organic vapor cartridge(s)
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister
(APF = 50) Any powered, air-purifying respirator with a tight-fitting facepiece and organic vapor cartridge(s)
(APF = 50) Any self-contained breathing apparatus with a full facepiece
(APF = 50) Any supplied-air respirator with a full facepiece
Up to 1000 ppm:
(APF = 2000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
Emergency or planned entry into unknown concentrations or IDLH conditions:
(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
Escape:
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus
Important additional information about respirator selection
Exposure Routes
inhalation, skin absorption, ingestion, skin and/or eye contact
Symptoms
Irritation eyes, skin, respiratory system; nausea, vomiting; chest pain; lassitude (weakness, exhaustion); stupor, convulsions; in animals: liver, kidney damage
Target Organs
Eyes, skin, respiratory system, cardiovascular system, central nervous system, liver, kidneys
See also: INTRODUCTION   See ICSC CARD: 0320