NIOSH Publication No. 2005-151:

NIOSH Pocket Guide to Chemical Hazards

September 2005

Strychnine

CAS
57-24-9

C21H22N2O2

RTECS
WL2275000
Synonyms & Trade Names

Nux vomica, Strynchnos
DOT ID & Guide
1692 / 151

Exposure
Limits

NIOSH REL: TWA 0.15 mg/m3
OSHA PEL: TWA 0.15 mg/m3
IDLH
3 mg/m3 See: 57249
Conversion
Physical Description
Colorless to white, odorless, crystalline solid. [pesticide]
MW: 334.4
BP: Decomposes
MLT: 514°F
Sol: 0.02%
VP: Low
IP: ?

Sp.Gr: 1.36
Fl.P: ?
UEL: ?
LEL: ?

Combustible Solid, but difficult to ignite.
Incompatibilities & Reactivities

Strong oxidizers
Measurement Methods
NIOSH 5016
See: NMAM or OSHA Methods
Personal Protection & Sanitation
(See protection)
Skin: Prevent skin contact
Eyes: No recommendation
Wash skin: When contaminated
Remove: No recommendation
Change: Daily

First Aid
(See procedures)
Eye: Irrigate immediately
Skin: Soap wash promptly
Breathing: Respiratory support
Swallow: Medical attention immediately
Respirator Recommendations
NIOSH/OSHA
Up to 0.75 mg/m3:
(APF = 5) Any quarter-mask respirator. Click here for information on selection of N, R, or P filters.
Up to 1.5 mg/m3:
(APF = 10) Any particulate respirator equipped with an N95, R95, or P95 filter (including N95, R95, and P95 filtering facepieces) except quarter-mask respirators. The following filters may also be used: N99, R99, P99, N100, R100, P100. Click here for information on selection of N, R, or P filters.
(APF = 10) Any supplied-air respirator
Up to 3 mg/m3:
(APF = 25) Any supplied-air respirator operated in a continuous-flow mode
(APF = 25) Any powered air-purifying respirator with a high-efficiency particulate filter.
(APF = 50) Any air-purifying, full-facepiece respirator with an N100, R100, or P100 filter. Click here for information on selection of N, R, or P filters.
(APF = 50) Any self-contained breathing apparatus with a full facepiece
(APF = 50) Any supplied-air respirator with a full facepiece
Emergency or planned entry into unknown concentrations or IDLH conditions:
(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
Escape:
(APF = 50) Any air-purifying, full-facepiece respirator with an N100, R100, or P100 filter. Click here for information on selection of N, R, or P filters./Any appropriate escape-type, self-contained breathing apparatus
Important additional information about respirator selection
Exposure Routes
inhalation, ingestion, skin and/or eye contact
Symptoms
Stiff neck, facial muscle; restlessness, anxiety, increased acuity of perception; increased reflex excitability; cyanosis; tetanic convulsions with opisthotonos
Target Organs
central nervous system
See also: INTRODUCTION   See ICSC CARD: 0197   See MEDICAL TESTS: 0213